Madonna has been helping friend Rosie O'Donnell through her mid-life crisis

The actress comedian said she has been emailing the Material Girl for advice on going through the menopause.

During an interview on the Tyra Banks show, O'Donnell said she immediately turned to 50-year-old Madonna when her "hormone things" kicked in.

She said: "She's great, she's a lot like a big sister. When I started having my hormone things, I'm like, 'What the hell is going on?' she's like, 'Get the cream'."

Madonna and O'Donnell became close friends when they starred together in the 1992 film A League of Their Own.